Sean Paul takes the number one spot on this week's Big 10 with his catchy single 'Hold My Hand'! Watch it along with music videos from Jay-Z, Kid Cudi, Phoenix, Ludacris, Jason Derulo, Hot Chip, and more.

Rihanna kicks off this week's MTV Big 10 with her latest hit music video single 'Hard'! Watch it now along with music videos from Jay-Z, Lil Wayne, Kid Cudi, Phoenix, Ludacris, Jason Derulo, and more.

Paramore takes the number one spot on an all-new Big 10 with their hit 'Pan's Labyrinth' inspired music video 'Brick By Boring Brick'! Watch it now along with music videos from Sean Paul, Mos Def, Kid Cudi, Phoenix, Adam Lambert, and more.

Jared Leto and the boys of Thirty Seconds to Mars are back on top of the MTV Big 10 with their latest hit 'Kings and Queens.' Watch it along with the rest of the list, including music from Paramore, Sean Paul, Muse, Lil Wayne, and more.

Indie rockers Vampire Weekend take the #1 spot on this week's Big 10 with their latest music video 'Cousins.' Watch it now along with the rest of the list, including music from Major Lazer, Rihanna, Sean Paul, Jay-Z, Mos Def, and more.

MTV's biggest artist of 2009, Beyonce, heads up the first Big 10 of 2010! Watch 'Video Phone' now, along with music videos from Thirty Seconds to Mars, Paramore, Boys Like Girls, Rihanna, Sean Paul, and more.

Lady Gaga's hit video 'Bad Romance' is the MTV Big 10's last #1 video of 2009! Watch it again along with music videos from Beyonce, Vampire Weekend, Anya Marina, Boys Like Girls, Rihanna, and more.

Canadian pop-synth phenom Lights heads up the number one spot on this week's edition of the Big 10! Watch 'Ice,' as well as hit music videos from Lady Gaga, Thirty Seconds to Mars, Paramore, Major Lazer, Boys Like Girls, and more.

Cobra Starship climbs to the top of the Big 10 with their first number one! Watch their hit video 'Hot Mess,' along with music from Beyonce, Anya Marina, Paramore, Thirty Seconds to Mars, Hedley, Major Lazer, and more.

Jay-Z and Alicia Keys' massive hit 'Empire State of Mind' makes it the top of the Big 10 this week! Watch it along with the rest of the list, including music videos from Beyonce, Vampire Weekend, Thirty Seconds to Mars, Paramore, and more.

Teen country-pop superstar Taylor Swift takes the top spot on this week's edition of the Big 10 with her hit music video 'Fifteen.' Watch it now along with music from Lady Gaga, Rihanna, Vampire Weekend, Shakira, Anya Marina, and more.

Jason Derulo gets his first #1 at the top of the Big 10 with his Imogen Heap-infused hit 'Whatcha Say.' Watch it along with music videos from Jay-Z, Lady Gaga, Beyonce, Muse, Vampire Weekend, and more.

Death Cab for Cutie's hit music videos for their New Moon single 'Meet Me on the Equinox' takes the top spot on the Big 10! Watch it along with hit videos from Taylor Swift, Jay-Z, Lights, Lady Gaga, Rihanna, and more.

Miley Cyrus proclaims her love for Britney and Jay-Z at the top of the Big 10! Watch 'Party in the U.S.A.' along with music videos from Green Day, Owl City, Taylor Swift, Jay-Z, Cobra Starship and more.

Rock icon's the Foo Fighters kick off an all-new edition of the MTV Big 10 with 'Wheels,' their new video off of their upcoming Greatest Hits album! Check it out along with videos from Green Day, Taylor Swift, Alicia Keys, and more.

Former American Idol winner Jordin Sparks takes her first number one spot on the MTV Big 10! Watch her latest hit single 'S.O.S. (Let the Music Play),' along with music from Death Cab for Cutie, St. Vincent, Owl City, 3Oh!3, and more.

UK rockers Muse follow up their recent performance at the 2009 VMA's with a number one spot on the MTV Big 10! Watch their hit video 'Uprising,' along with music from Foo Fighters, Death Cab for Cutie, Jason Derulo, St. Vincent, and more.

German pop-rockers Tokio Hotel make their debut at the top of the Big 10 with their latest hit single 'Automatic.' Watch it along with the rest of the list, including music by Foo Fighters, Miley Cyrus, T.I., Death Cab for Cutie, and more.

90's rock legends Pearl Jam take the number one spot on this week's Big 10 with their hit single 'The Fixer' off of their critically acclaimed album 'Backspacer.' Watch it along with videos by Muse, Foo Fighters, Miley Cyrus, and more.

Jay-Z gets cinematic in his latest Big 10 number one video 'Run This Town' featuring Rihanna and Kanye West. Watch it along with music videos by Pearl Jam, Muse, Hedley, Three Days Grace, and more.

Metric takes the top spot on the MTV Big 10 with their latest hit music video 'Help I'm Alive.' Watch it along with the rest of the list, including music from Pearl Jam, Muse, Mary J. Blige, Jordin Sparks, and more.

Paramore light up this week's Big 10 with their chart topping track 'Ignorance.' Watch it now along with music videos by Jay-Z, Asher Roth, Pearl Jam, Tokio Hotel, Madonna, and more.

Indie rockers Animal Collective ride the buzz from their critically acclaimed new album 'Merriweather Post Pavillion' straight to the top of the Big 10! Watch 'Summertime Clothes,' along with videos by Jay-Z, Pearl Jam, and more.

Kid Cudi (with some help from Kanye West and Common) takes the number one spot on the MTV Big 10! Watch it along with the rest of the list, including music videos by Animal Collective, Metric, Jay-Z, Asher Roth, and more.

Jack White's latest band of rockers, the Dead Weather, finish their ascent to the top of the Big 10. Watch their rockin' track 'Treat Me Like Your Mother,' along with videos by Kid Cudi, Metric, Jay-Z, MSTRKRFT, and more.

Eminem takes the top spot on this week's edition of the Big 10 with his powerful Freddie Mercury fueled single 'Beautiful.' Watch it along with music from Coldplay, Paramore, Nicole Holness, and more.

The King of Rap takes the top spot on the MTV Big 10 with his mainstream hip hop call out 'D.O.A. (Death of Auto-Tune).' Watch it now, along with videos from Kid Cudi, Kelly Clarkson, Coldplay, and more.

Green Day hit the top of the Big 10 with their second number one video from '21st Century Breakdown.' Watch '21 Guns,' along with music from Animal Collective, Kelly Clarkson, and more.

The Big 10's going Gaga this week as Lady Gaga takes the top spot with her hit video 'Paparazzi.' Watch it now along with videos by Eminem, Beyonce, the Dead Weather, Kid Cudi, and more.

Indie hipsters MGMT take the reigns at the top of this week's Big 10 with their latest mind-warping single 'Kids.' Watch it now along with videos by Beyonce, the Dead Weather, and more.

Kings of Leon climb to the top of the Big 10 with their new hit video 'Notion.' Watch it along with videos by Kanye West, Eminem, Britney Spears, and more.

The Pussycat Dolls are back on top of the Big 10 with their scorching hot Summer single 'Hush Hush: Hush Hush.' Watch it along with videos by MGMT, Jay-Z, Eminem, and more.

Reigning hip hop king Eminem climbs to the top of the MTV Big 10 with his controversial hit video '3 A.M.' Watch it along with music by Yeah Yeah Yeahs, Green Day, and more.

Canadian rockers Alexisonfire take the top spot on the Big 10 chart with their hit 'Young Cardinals.' Watch it now along with videos by Kings of Leon, MGMT, Lady Gaga, and more.

Indie up and comers Passion Pit take their first number one spot on the Big 10! Watch 'The Reeling,' along with videos by Billy Talent, Kings of Leon, Linkin Park, and more.

Scotish rockers Glasvegas finally climb to the top of the Big 10 with their video 'Flowers and Football Tops.' Watch it along with videos by Passion Pit, Billy Talent, Pussycat Dolls, and more.

Green Day skyrocket to the top of this week's Big 10 with their hit video 'Know Your Enemy.' Watch it now along with videos by Passion Pit, Asher Roth, Billy Talent, and more.

Death Cab for Cutie makes their first appearance at the top of the Big 10 with their latest single 'Grapevine Fires.' Watch it along with videos by Katy Perry, Eminem, Alexisonfire, and more.

Canadian indie rockers Metric take the top spot of the Big 10 with their hit single 'Gimme Sympathy.' Watch it along with the rest of the chart, including videos by Passion Pit, Asher Roth, and more.

Karen O. and the Yeah Yeah Yeahs take the number one spot on an all-new Big 10. Watch Zero along with new videos by Passion Pit, Katy Perry, and more.

The Pussycat Dolls are at the head of the pack with their 'Slumdog Millionaire' cover 'Jai Ho! (You Are My Destiny).' Watch it along with the rest of the Big 10 including music by Green Day, Passion Pit, and more.

Britney Spears is back on top of the Big 10 with her third single from 'Circus.' Watch 'If U Seek Amy,' along with videos by Death Cab for Cutie, Green Day, Glasvegas, and more.

Weezy's back at the top as Lil Wayne's genre hopping hit 'Prom Queen' takes the top spot on the Big 10. Watch it along with videos by Asher Roth, Metric, and more.

Indie hip hop phenoms The Cool Kids take hold of their first number one spot with 'Pennies.' Watch it along with the rest of the list, including videos by Lil Wayne, Eminem, and more.

Flo Rida completes his rise to the top of the Big 10 with his latest hit video 'Right Round.' Watch it along with videos by Lil Wayne, Ciara, Franz Ferdinand, and more.

T.I. may be going to jail, but that won't stop him from taking the top spot on the Big 10! Watch 'Dead and Gone,' along with the rest of the list, including videos by Lil Wayne, the Pussycat Dolls, Ciara, Yeah Yeah Yeahs, and more.

White Lies finish their climb to the top of the Big 10 with their hit single 'To Lose My Life.' Watch it along with the rest of the list, including videos by Flo Rida, Britney Spears, Pussycat Dolls, and more.

Kelly Clarkson brings pop back to the top of the Big 10 with 'My Life Would Suck Without You.' Watch it along with videos by Lil Wayne, Britney Spears, Kanye West, Pussycat Dolls, and more.

Coldplay once again climb to the top of the Big 10 with their puppet-centric video 'Life in Technicolor ii.' Watch it along with the rest of the list including videos by My Chemical Romance, Flo Rida, the Cool Kids, and more.